Abstract: Objective: To investigate the curative effect of non-invasive mechanical ventilation combined with nitroprusside sodium on acute cardiac pulmonary edema(ACPE).Methods: Thirty-three cases of ACPE were collected and divided randomly into group A(non-invasive mechanical ventilation combined with nitroprusside sodium therapy),group B(nitroprusside sodium therapy) and group C(conventional therapy).The heart rate(HR),respiratory rate(R),mean arterial pressure(MAP) and saturation of blood oxygen(SpO₂) of all the patients were measured before and after treatment,and the curative effect was judged according to the symptoms and lung rattle.Results: Compared with group B and C,R in group A decreased and SpO₂ rose after treatment for more than 15 minutes(P<0.05 to P<0.01),and the MAP decreased obviously 60 minutes later(P<0.01);group A could obviously raise the success rate of salvage and shorten the salvage time compared to group B and C(P<0.05).Conclusions: Non-invasive mechanical ventilation combined with nitroprusside sodium can obviously decrease the RR and MAP,improve the SpO₂,raise the success rate of salvage and shorten the salvage time in treating patients with ACPE.