陈永锋, 曹立宇, 黄全顺, 张凯. S100A4蛋白在口腔鳞状细胞癌的表达及其意义[J]. 蚌埠医学院学报, 2007, 32(6): 662-664,765.
    引用本文: 陈永锋, 曹立宇, 黄全顺, 张凯. S100A4蛋白在口腔鳞状细胞癌的表达及其意义[J]. 蚌埠医学院学报, 2007, 32(6): 662-664,765.
    CHEN Yong-feng, CAO Li-yu, HUANG Quan-shun, ZHANG Kai. Expressions of S100A4 protein in oral squamous cell carcinoma and its significance[J]. Journal of Bengbu Medical College, 2007, 32(6): 662-664,765.
    Citation: CHEN Yong-feng, CAO Li-yu, HUANG Quan-shun, ZHANG Kai. Expressions of S100A4 protein in oral squamous cell carcinoma and its significance[J]. Journal of Bengbu Medical College, 2007, 32(6): 662-664,765.

    S100A4蛋白在口腔鳞状细胞癌的表达及其意义

    Expressions of S100A4 protein in oral squamous cell carcinoma and its significance

    • 摘要: 目的: 探讨S100A4蛋白在口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)的表达及其意义。方法: 采用免疫组化SP法检测61例OSCC组织和20例正常口腔黏膜(NOM)组织中S100A4蛋白的表达情况,并分析S100A4蛋白的表达与OSCC临床病理特征之间的关系。结果: NOM组织中S100A4蛋白不表达,在OSCC组织中S100A4蛋白的表达率为24.6%,两者差异有统计学意义(P<0.05)。在OSCC中,S100A4蛋白的表达与组织学分级无关(P>0.05),与淋巴结转移有一定关系(P<0.01);结论: S100A4蛋白与OSCC的侵袭和转移有一定关系,是判断口腔鳞癌生物学行为、预测转移趋势的有价值指标之一。

       

      Abstract: Objective: To investigate the expressions of S100A4 protein in oral squamous cell carcinoma(OSCC) and its significance.Methods: Expression of S100A4 protein was detected by using immunohistochemistry SP method in 61 patients with OSCC and 20 cases of normal mucosa.Relationship between the expression of S100A4 protein and clinicopathological features was analyzed.Results: The positive expression rate of S100A4 protein was 24.6% in OSCC,but negative expression in NOM.The difference in the positive expression rate of S100A4 protein was statistically significant between the OSCC and NOM(P<0.05).Expression of S100A4 protein in OSCC had positive correlation with lymph node metastasis(P<0.01),and no correlation with histological grading(P>0.05).Conclusions: S100A4 protein is related with invasion and metastasis of OSCC.Expression of S100A4 protein is significantly associated with tumor progression in OSCC,which was one of the valuable markers for predicting biological behavior and trend of metastasis of OSCC.

       

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