赵福友, 王子安, 郑荣生. 小牛脾提取物注射液联合化疗治疗晚期胃癌的疗效观察[J]. 蚌埠医学院学报, 2010, 35(8): 779-781.
    引用本文: 赵福友, 王子安, 郑荣生. 小牛脾提取物注射液联合化疗治疗晚期胃癌的疗效观察[J]. 蚌埠医学院学报, 2010, 35(8): 779-781.
    ZHAO Fu-you, WANG Zi-an, ZHENG Rong-sheng. Efficacy of calf spleen extraction injection combined chemotherapy in the treatment of andvanced gastric cancer[J]. Journal of Bengbu Medical College, 2010, 35(8): 779-781.
    Citation: ZHAO Fu-you, WANG Zi-an, ZHENG Rong-sheng. Efficacy of calf spleen extraction injection combined chemotherapy in the treatment of andvanced gastric cancer[J]. Journal of Bengbu Medical College, 2010, 35(8): 779-781.

    小牛脾提取物注射液联合化疗治疗晚期胃癌的疗效观察

    Efficacy of calf spleen extraction injection combined chemotherapy in the treatment of andvanced gastric cancer

    • 摘要: 目的:评价小牛脾提取物注射液辅助紫杉醇(PTX)+替加氟(FT-207)+亚叶酸钙(LV)治疗晚期胃癌的疗效。方法:采用信封法将43例晚期胃癌患者随机分为2组,治疗组20例采用小牛脾提取物注射液辅助PTX+FT-207+LV治疗;对照组23例单用PTX+FT-207+LV治疗。治疗组于开始化疗时即给予小牛脾提取物注射液静脉滴注8ml/d,连续应用10天。分别于治疗前后对患者外周血白细胞、肝肾功能、消化道反应、生存情况、疗效进行评价。结果:治疗组及对照组的总有效率分别为65.0%及34.8%,差异有统计学意义(P<0.05)。治疗组及对照组中位生存时间分别为12个月和10个月(P>0.05),治疗组及对照组1年生存率分别为60.0%及21.7%,差异有统计学意义(P<0.05)。治疗组生活质量显著改善,与对照组比较差异有统计学意义(P<0.05)。治疗组白细胞减少程度均好于对照组。结论:小牛脾提取物注射液联合PTX+FT-207+LV可以增强疗效,减轻骨髓毒性及消化道反应,提高患者生存质量和化疗耐受性,值得临床推广。

       

      Abstract: Objective: To evaluate the efficacy,side-effects and quality of life in the advanced gastric cancer patients treated by paclitaxel (PTX) plus tegafur (FT-207) and leucovorin (LV) with or without calf spleen extraction injection.Methods: Forty-three eligible patients were randomly assigned to the treatment group and control group.In the treatment group,20 patients were treated with PTX+FT-207+LV+calf spleen extraction injection.In the control group,the regimen was the same as in the treatment group except calf spleen extraction injection.Results: Overall response rates were 65.0% and 34.8% (P<0.05) in the treatment group and control group,respectively.The median survival time was 12 months versus 10 months (P>0.05) in the treatment group and control group,respectively.The 1-year survival rate for treatment group and control group was 60.0% versus 21.7% (P<0.05),respectively.The clinical efficacy and the frequence of leukocyte reduction were better in the treatment group than in control group,the quality of life were improved more significantly than those in control group (P<0.05).Conclusions: Calf spleen extraction injection plus PTX+FT-207+LV regimen can improve the efficacy of the treatment,reduce the chemotherapy related toxicities of digestive tract and bone marrow,improve the quality of life and the tolerance of chemotherapy of advanced gastric cancer patients.

       

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