Abstract: Objective: To investigate the risk factors of stress complications in patients with multiple trauma.Methods: The clinical data of stress complications in 64 patients with multiple trauma were analyzed by univariate and multivariate binary Logistic regression.The data of routine blood,c-reactive protein,blood sugar,blood electrolytes,blood gas analysis,indexes of liver and kidney function,serum total iodine thyroid glycine(TT3),serum free thyroid original three iodine glycine(FT3),total serum thyroxine(TT4),serum free thyroid hormone,thyroid stimulating hormone,adrenocorticotropic hormone(ACTH),blood cortisol(COR),growth hormone,cytokine interleukin(IL)-1,IL-6,IL 8,IL-10 and tumor necrosis factor(TNF-α) in all cases were investigated.Results: The stress ulcer and acute respire distress syndrome of stress complications were found in 48 cases.The differences of the grade Ⅱ scores of acute phsiology and chronic health(APACHⅡ),COR,ACTH,TT3,FT3,TT4,IL-6,IL-8,IL-10 and TNF-α between patients with stress complications and patients without stress complications were statistically significant(P<0.05 to P<0.01).The multivariate analysis showed that APACHⅡ grade,cortisol,TT4,IL-6 and IL-10 were the independent risk factor of early stress complication(P<0.05 to P<0.01).Conclusions: The levels of APACH gradeⅡ,Cortisol,TT4,IL-6 and IL-10 are obviously correlated with the stressgastrointestinalbleeding and respiratory distress syndrome in patients with multiple trauma.