Abstract: Objective: To explore the effects of the eating time on blood pressure of patients during hemodialysis.Methods: The clinical data of 25 patients with hypotension during hemodialysis were investigated using self-control method.The patients were treated with fasting during hemodialysis,eating 250 g food within 2 h of hemodialysis and at 3 h after hemodialysis for 2 weeks,respectively.The mean arterial pressure at 30 min before and after eating,and every hour mean arterial pressure before the hemodialysis and during hemodialysis were analyzed.Results: The differences of mean arterial pressure before and after eating and before the hemodialysis and during hemodialysis,the occurrence rates of hypotension and symptomatic hypotension,and nursing intervention between 3 groups were statistically significant(P<0.01).The differences of all indexes of patients treated with eating at 3 h after hemodialysis and other two groups were statistically significant(P<0.01).The differences of mean arterial pressure before the hemodialysis and number of stop hemodialysis caused by hypotension between 3 groups were not statistically significant(P>0.05).Conclusions: For hypotension-prone patients,the eating time should be within 2 h hours of hemodialysis,and prohibit at 3 h after hemodialysis,which can prevent the hypotension.