Abstract: Objective: To evaluate the efficacy and safety of trabeculectomy for glaucoma in high intraocular pressure.Methods: Surgery was performed on 21 patients (24 eyes) with uncontrolled intraocular pressure with drug.Visual acuity, filtering bled, anterior chamber, intraocular pressure (IOP) and complications were observed after operation.Results: All of the 24 eyes underwent surgery successfully.All patients were followed up for 2-15 months.The IOP of 20 eyes were lower than 21 mmHg without any anti-glaucoma drug after the operation.After using part medicine IOP of 2 eyes were controlled.The visual acuity improved in 13 eyes (54.17%), visual acuity remained unchanged in 6 eyes (24%).Conclusions: To keep the vision function, trabeculectomy should be performed for glaucoma patients with persistent high intraocular pressure actively.It is safe and it can obtain satisfactory clinical effect with suitable management.