Objective To investigate the application value of modifiedtransumbilical single-port laparoscopic myomectomy in patients with uterine fibroids. and its effects on pain degree and stress response.

Methods One hundred and six patients with uterine fibroids were selected, and divided into the observation group and control group according to the randomized numerical table method (53 cases each group). The control group were treated with traditional multi-port laparoscopic myomectomy, and the observation group were treated with modified transumbilical single-port laparoscopic myomectomy. Two groups were followed up for 1 month after surgery. The intraoperative and postoperative parameters, pain levels at different time points, preoperative and postoperative 1 d stress reactions and postoperative complications within 1 month were compared between two groups.

Results The tumor removal, anal defecation, postoperative defecation, postoperative bed and hospitalization time in the observation group were shorter than those in control group (P ＜ 0.01), the operation time was longer than that in control group (P ＜ 0.05), the intraoperative bleeding was less than that in control group (P ＜ 0.01), and the cosmetic effect scores were higher than that in control group at 1 month after operation (P ＜ 0.01). After 1 to 3 days of operation, the VAS scores in two groups showed a gradually decreasing trend (P ＜ 0.05), and the VAS scores in the observation group were significantly lower than those in control group at all time points (P ＜ 0.01). At 1 day after operation, the serum superoxide dismutase levels in two groups were lower than those before operation (P ＜ 0.05), but which in the observation group was significantly higher than that in control group (P ＜ 0.01). The serum levels of malondialdehyde, norepinephrine and β-endorphin in two groups after 1 day of surgery were higher than those before surgery (P ＜ 0.05), but these in the observation group were significantly lower than those in control group (P ＜ 0.01). There was no statistical significance in the total incidence of complications within 1 month after surgery between two groups (P ＞ 0.05).

Conclusions The application of modified transumbilical single-port laparoscopic myomectomy in patients with uterine fibroids can prolong the operation time, but it can significantly reduce the intraoperative blood loss, shorter the time of tumor removal, promote rapid postoperative recovery of patients, improve cosmetic effects, reduce the degree of pain and relieve the stress response of patients, and is good short-term safety.