Abstract: Objective: To explore the clinical efficiency and safety of pazufloxacin sodium chloride injection in treatment of lower respiratory infection.Methods: The clinical effect of pazufloxacin on lower respiratory infection was observed and compared with that of levofloxacin.Thirty patients were randomly divided into treatment group(16 cases) and control group(14 cases) receiving pazufloxacin and levofloxacin,respectively,for 7 to 14 days.Results: Pazufloxacin and levofloxacin were used for (8.74±2.28) days and(8.47±2.05) days,respectively(P>0.05).The total response rates were 93.75% and 92.86% in the treatment group and control group,respectively(P>0.05).There was no side difference in common data between the two groups.During the course of treatment,no side effect related to the drug occurred.Conclusions: It is safe and effective to treat lower respiratory infection with pazufloxacin sodium chloride injection.