王亮, 王忠荣, 李龙, 孙华. Cajal间质细胞在先天性巨结肠发病中的作用[J]. 蚌埠医学院学报, 2007, 32(6): 682-683,766.
    引用本文: 王亮, 王忠荣, 李龙, 孙华. Cajal间质细胞在先天性巨结肠发病中的作用[J]. 蚌埠医学院学报, 2007, 32(6): 682-683,766.
    WANG Liang, WANG Zhong-rong, LI Long, SUN Hua. Role of interstitial cells of Cajal in Hirschsprung disease[J]. Journal of Bengbu Medical College, 2007, 32(6): 682-683,766.
    Citation: WANG Liang, WANG Zhong-rong, LI Long, SUN Hua. Role of interstitial cells of Cajal in Hirschsprung disease[J]. Journal of Bengbu Medical College, 2007, 32(6): 682-683,766.

    Cajal间质细胞在先天性巨结肠发病中的作用

    Role of interstitial cells of Cajal in Hirschsprung disease

    • 摘要: 目的: 观察Cajal间质细胞(interstitial cells of Cajal,ICCs)在先天性巨结肠患儿狭窄段和扩张段的分布情况,探讨ICCs在巨结肠发病中的作用。方法: 应用免疫组化PV法,检测32例先天性巨结肠患儿和10例对照组肠标本ICCs,光镜下观察不同肠段肌间神经丛及环肌层内ICCs分布情况。结果: 在对照组及巨结肠扩张段,ICCs大量分布在肌间神经丛周围及环肌层内,并形成网络结构。在狭窄段,肠壁各层ICCs细胞密度明显减少甚至消失,正常所见的网络结构遭到破坏。结论: Cajal间质细胞分布异常是先天性巨结肠病理改变之一,可能是该病重要的发病机制,参与肠运动障碍的发生。

       

      Abstract: Objective: To observe the distribution of interstitial cells of Cajal(ICCs) in Hirschsprung disease(HD),and investigate the role of ICCs in HD.Methods: The distribution of ICCs was examined in 32 patients with HD and 10 normal controls by PV immunohistochemistry.Results: In bowels from normal controls and ganglionic segment from HD,the moderate to large amount of ICCs were observed around the myenteric plexus and at the circular muscle layer.ICCs in these domain appeared as a network structure.On the contrary,the number of ICCs was significantly decreased or even disappeared in between the muscle layers of the ganglionic segment in HD.Conclusions: Abnormal distribution of ICCs in the bowel affected by HD may explain the bowel dysmotility seen in these patients.

       

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