张进, 王长俊, 谢江, 陈芳. 绞股蓝总皂苷对阿霉素致大鼠急性心脏毒性的保护作用[J]. 蚌埠医学院学报, 2007, 32(4): 401-403.
    引用本文: 张进, 王长俊, 谢江, 陈芳. 绞股蓝总皂苷对阿霉素致大鼠急性心脏毒性的保护作用[J]. 蚌埠医学院学报, 2007, 32(4): 401-403.
    ZHANG Jin, WANG Chang-jun, XIE Jiang, CHEN Fang. Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats[J]. Journal of Bengbu Medical College, 2007, 32(4): 401-403.
    Citation: ZHANG Jin, WANG Chang-jun, XIE Jiang, CHEN Fang. Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats[J]. Journal of Bengbu Medical College, 2007, 32(4): 401-403.

    绞股蓝总皂苷对阿霉素致大鼠急性心脏毒性的保护作用

    Protective effect of gypenosides on adriamycin induced acute cardiotoxicity in rats

    • 摘要: 目的: 观察绞股蓝总皂苷(gypenosides,Gps)对阿霉素致急性大鼠心脏毒性的保护作用,探讨其作用机制。方法: 雄性SD鼠24只,随机分为正常对照组(normal control,NC)、阿霉素组(adriamycin,ADR)和绞股蓝总皂苷组(Gps)。第3组给予4%绞股蓝总皂苷400mg·kg-1·d-1,分早晚2次灌胃,其它两组灌注等量生理盐水,连续5天。第6天一次性腹腔注射阿霉素10mg/kg复制大鼠急性心脏毒性模型,利用PowerLab数据采集和分析系统采集心室内压并分析心功能,检测心肌组织超氧化物歧化酶(superoxide dismutase,SOD)活性和丙二醛(malondialdehyde,MDA)的含量。结果: 与NC组相比,阿霉素组左室收缩峰压(left ventricular systolic pressure,LVSP)、左室内压最大上升/下降速率(maximal rates of pressure development anddecline,±dp/dtmax)、SOD的活性均显著降低(P<0.01),MDA含量显著升高(P<0.01)。与ADR组相比,Gps组的LVSP、±dp/dtmax和SOD均显著升高(P<0.01),MDA下降(P<0.05)。结论: 绞股蓝总皂苷可减轻阿霉素对心脏的毒性作用,明显改善大鼠的心功能。

       

      Abstract: Objective: To observe the protective effect of gypenosides (Gps) on adriamycin (ADR) induced acute cardiotoxicity in rats.Methods: Rats in Gps group received gypenosides 200 mg/kg orally twice a day for five days.In the meanwhile, the saline was given to ADR group and normal rats as controls.At the sixth day, the acute heart toxicity was induced by intraperifoneal injecting ADR (10 mg/kg).Subsequently, the functions of cardiac muscle, such as left ventricular systolic pressure (LVSP) and left verfricle maximal rates of pressure development and decline (+dp/dtmax), as well as the activity of SOD and content of MDA were measured.Results: LVSP, +dp/dtmax and the activity of SOD in rats of ADR group were significantly lower, and the content of MDA was higher than those in controls (P<0.01).LVSP, +dp/dtmaxand the activity of SOD in rats of Gps group were significantly higher and the content of MDA was significantly lower than those without giving gypenosides (P<0.05-P<0.01).Conclusions: Gyp secure cardiac muscles and their function from adriamycin impairment.

       

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