Abstract: Objective:To compare the effects and side effects of EOF (oxaliplatin combined with epirubicin and 5-Fluorouacil/leucovorin) with XELOX(oxaliplatin combined with xeloda) in treatment of patients with advanced gastric cancer. Methods:Among 75 patients with advanced gastric cancer,39 cases received EOF treatment and 36 cases received XELOX treatment. The efficacy and toxicity were evaluated after 2 therapy courses. Every therapy course included 3 weeks. Results:The overall effectve rate was 43.6% in EOF group,and 41.7% in XELOX group. There was no significant difference between the two groups(P>0.05). The incidence of hand-foot syndrome in XELOX group was higher than that in EOF group(P<0.01),but that of myelosuppression,nausea,vomiting and alopecie in EOX group higher than that in XEL0X group(P<0.01). Conclusions:The treatment of EOF and XELOX shows well-confirmed effects for advanced gastric cancer. XELOX is more convenient and suitable for the elder or weaker patients,but EOF is more suitable for the recurrent patients.