Abstract: Objective: To explore the clinical diagnosis and treatment of progressive hemorrhage injury (PHI) due to craniocerebral trauma.Methods: The clinical data of 46 patients with PHI were analyzed retrospectively,and the clinical features were discussed according to the Glasgow coma score at admission,first CT time after injury,hematoma type and PHI distribution.Results: The PHI was most often detected in patients with severe primary brain injury or receiving early CT rescue after injury;among the 46 PHI cases,25 had intracerebral hematoma,11 epidural hematoma,7 subdural hematoma and 3 subarachnoid hemorrhages.Satisfactory results were observed in 20 cases,slight disability in 12,sever disability in 8 and mortality in 6.Conclusions: Patients with severe traumatic brain injury,especially those receiving CT examination within 2 hours after injury should be rechecked within 6 hours to detect PHI.Early diagnosis and treatment may help to improve the patients' cure rate and reduce the mortality and rate of disability.