慢性阻塞性肺疾病患者C反应蛋白水平变化及其临床意义

Changes of the level of C reactive protein in patients with chronic obstructive pulmonary disease and its clinical significance

摘要: 目的:探讨C反应蛋白(C reactive protein,CRP)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)不同时期的水平变化及其临床应用价值。方法:检测64例COPD急性加重期患者(AECOPD)与62例缓解期患者的血清CRP水平、白细胞计数(WBC)及中性粒细胞比值(NE%)。结果:AECOPD患者CRP为(53.8±15.3)mg/L,缓解期为(6.4±5.8)mg/L,差异有统计学意义(P<0.01);AECOPD患者CRP阳性率为96.88%,显著高于WBC和NE%的阳性率(P<0.01和P<0.05)。结论:COPD患者CRP值在急性加重期明显升高,血清CRP水平是AECOPD诊断的优选指标。

Abstract: Objective: To observe C-reactive protein(CRP) level variation in patients with chronic obstructive pulmonary disease(COPD) and to investigate its clinical significance.Methods: The serum CRP level of 64 patients with COPD at acute exacerbation(AECOPD) and 62 patients at stable stage was measured,and the white blood cells(WBC) and percentage of neutrophils(NE%) were also collected.Results: The serum CRP level of AECOPD patients(53.8±15.3) mg/L was significantly higher than that of the patients at the stable stage(6.4±5.8) mg/L(P<0.01);the positive rate of the serum CRP of AECOPD patients was significantly higher(96.88%) than that of WBC(P<0.01) and NE%(P<0.05).Conclusions: The serum CRP level of COPD patients increases significantly at the acute exacerbation stage and it is a preferential index in diagnosis of AECOPD.