去氧氟尿苷治疗晚期胃癌、大肠癌近期疗效及副作用观察

Study on the efficacy and safety of doxifluridine in treatment of advanced gastric cancer and colorectal cancer

摘要: 目的: 观察去氧氟尿苷治疗老年晚期胃癌、大肠癌患者疗效和副作用。方法: 去氧氟尿苷200 mg,每天4次口服,连用14天,休息7天,重复2~3周期。结果: 20例晚期胃及大肠癌患者,完全缓解0例,部分缓解6例,好转9例,无效5例,总有效率30%,毒副反应轻微,白细胞Ⅰ~Ⅱ度减少5例,血小板Ⅰ度减少2例,恶心、呕吐反应Ⅰ~Ⅱ度3例,无明显心、肝、肾脏器毒性。结论: 去氧氟尿苷治疗晚期老年胃癌大肠癌有一定疗效,毒副反应轻微。

Abstract: Objective: To evaluate the efficacy and safety of doxifluridine in treatment of old and weak patients with advanced gastric and colorectal cancer.Methods: Twenty cases of advanced gastric and colorectal cancer were given doxifluridine 200 mg four times daily for 14 days,followed by a week rest.The regime was repeated for 2-3 cycles.Results: Among the patients,CR was found in 0 cases,PR in 6 cases,SD in 9 cases and PD in 5 cases.the overall response rate was 30%.There were few adverse events.WHO grade Ⅰ/Ⅱ leukopenia occurred in 5 cases(25%),grade I thrombocytopenia occurred in 2 cases(10%),gradeⅠ/Ⅱ nausea and vomiting in 3 cases(15%),and the damage to the liver and kidney and heart function was not obvious.Conclusions: Doxifluridine has certain effect on patients with advanced gastric and colorectal cancer,with slight toxin or side effects.