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三氧化二砷对鼠恶性黑素瘤B16细胞凋亡的影响

马佳, 沈继龙, 黄桦, 陈素莲, 陈治文

马佳, 沈继龙, 黄桦, 陈素莲, 陈治文. 三氧化二砷对鼠恶性黑素瘤B16细胞凋亡的影响[J]. 蚌埠医科大学学报, 2006, 31(3): 233-234.
引用本文: 马佳, 沈继龙, 黄桦, 陈素莲, 陈治文. 三氧化二砷对鼠恶性黑素瘤B16细胞凋亡的影响[J]. 蚌埠医科大学学报, 2006, 31(3): 233-234.
MA Jia, SHEN Ji-long, HUANG Hua, CHEN Su-lian, CHEN Zhi-wen. The effect of arsenic trioxide on apoptosis of melanoma B16 cells[J]. Journal of Bengbu Medical University, 2006, 31(3): 233-234.
Citation: MA Jia, SHEN Ji-long, HUANG Hua, CHEN Su-lian, CHEN Zhi-wen. The effect of arsenic trioxide on apoptosis of melanoma B16 cells[J]. Journal of Bengbu Medical University, 2006, 31(3): 233-234.

三氧化二砷对鼠恶性黑素瘤B16细胞凋亡的影响

基金项目: 

安徽省教育厅自然科学研究资助项目(2006kj351b)

详细信息
    作者简介:

    马佳(1977-),女,讲师.

  • 中图分类号: R739.5;O613.63

The effect of arsenic trioxide on apoptosis of melanoma B16 cells

  • 摘要: 目的: 探讨三氧化二砷(As2O3)对鼠恶性黑素瘤B16细胞诱导凋亡的影响。方法: 采用流式细胞术(FCM)检测不同浓度的As2O3诱导B16细胞的早期凋亡率、晚期凋亡率和总凋亡率。结果: As2O3浓度分别为5μmol/L、10μmol/L、20μmol/L时,B16细胞的早期凋亡率分别为7.18%、21.1%、3.59%,晚期凋亡率分别为2.63%、5.35%、6.34%,总凋亡率分别为9.81%、26.45%、9.93%。结论: B16细胞的早期凋亡率和晚期凋亡率对As2O3有浓度依赖关系,高浓度的As2O3使B16细胞出现坏死。
    Abstract: Objective: To study the effect of arsenic trioxide on apoptosis of melanoma B16 cells.Methods: Early apoptosis rate,late apoptosis rate and total apoptosis rate in melanoma B16 cells were analysed by flow cytometry.Results: At the doses of arsenic trioxide were 5 μmol/L,10 μmol/L,or 20 μmol/L,the early apoptosis rates in melanoma B16 cells were 7.18%,21.1%,and 3.59%,respectively;the late apoptosis rates were 2.63%,5.35%,and 6.34%,respectively;the total apoptosis rates were 9.81%,26.45%,and 9.93%,respectively.Conclusions: The early apoptosis rate and the late apoptosis rate in melanoma B16 cells have dose-dependent relationship with arsenic trioxide.
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出版历程
  • 收稿日期:  2005-12-25

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