肺心病患者急性发作期血浆D二-聚体及C反应蛋白测定的临床意义

Clinical significance of the levels of serum D-dimer and C reative protein in patients with pulmonary heart disease

摘要: 目的:探讨慢性肺源性心脏病(肺心病)患者急性发作期血浆D-二聚体(D-dimer,DDR)和C反应蛋白(C reactive protein,CRP)变化的临床意义。方法:采用全自动生化分析法测定肺心病患者(41例)与健康对照组(30名)血浆DDR及CRP水平。结果:肺心病患者血浆DDR及CRP浓度均较健康对照组明显增高(P<0.01)。结论:肺心病患者CRP浓度增高提示肺部感染病理生理过程。DDR反映肺心病患者血液高凝状态,有助于肺部微小血栓的诊断。

Abstract: Objective: To explore the clinical significance of D-dimer(DDR) and C reative protein(CRP) in patients with chronic pulmonary heart disease.Methods: The levels of DDR and CRP were measured in the plasma of 41 patients with chronic pulmonary heart disease and 30 healthy controls.Results: The plasma levels of DDR and CRP were significantly different between the patients with chronic pulmonary heart disease and the healthy controls(P<0.01).Conclusions: The increase of serum CRP indicates pathophysiology of pneumonia.Serum DDR reveals the patients' hypercoagulabale state and is of helps to the diagnosis of microthromb in the lung.