Abstract: Objective: To observe and compare the influence of cardiovascular response between streamlined liner pharynx airway (SLIPA) and trachea cannula in breast cancer patients. Methods: Eighty patients with mammary cancer of ASAⅠ-Ⅱ grade and no cardiovascular disorders were randomly divided into SLIPA group and trachea cannula group,each group induding 28 cases. Systolic blood pressure(SBP),diastolic blood pressure(DBP) and heart rate(HR) were monitored and recorded when the patients entered into operation room(T₀),before laryngeal mask insertion(T₁),1 minute after laryngeal mask insertion(T₂),3 minute after laryngeal mask insertion(T₃),5 minute after laryngeal mask insertion (T₄),when start operation (T₅),after operation (T₆),before laryngeal mask withdrawal(T₇),after laryngeal mask withdrawal immediately(T₈),and 5 minute after laryngeal mask withdrawal(T₉). Results: The results of SBP,DBP and HR in the SLIPA group at timepoints T₂,T₃,T₇,T₈ and T₉ were significantly better than that in the trachea cannula group(P < 0.05-P < 0.01). Conclusions: SLIPA could be a ideal airway veafication method fou braast cancer patients due to minior interffevences to the cardiovascular response.