Abstract: Objective: To detect the expression of vascuoar endothelial growth factor(VEGF) and investigate its relationship between clinicopathological features and molecular subtypes in breast cancer.Methods: The expressions of VEGF,estrogen receptor,progesterone receptor,human epidermal growth factor receptor 2(Her-2) and nuclear associated antigen-67 in breast cancer were detected by immunohistochemical method.The Her-2 gene level was measured by fluorescence in situ hybridization.The breast cancers were divided into four molecular subtypes according to the expression levels of estrogen receptor,progesterone receptor,Her-2 and nuclear associated antigen-67,the expression of VEGF in different subtypes was measured.Results: The positive rate of VEGF expression in breast cancer tissue was significantly higher than that in benign lesion tissue and para-carcinoma tissue(P<0.01).The positive rate of VEGF expression in breast cancer tissue with lymph node metastasis was significantly higher than that in breast cancer tissue without lymph node metastasis(P<0.05).The positive rate of VEGF expression increased with the increasing of histological grade and clinical stage(P<0.05 to P<0.01).The positive rate of VEGF expression in type Basal-like was higher than that in type Luminal A(P<0.05).Conclusions: VEGF involves the process of occurrence,development and metastasis of breast cancer,which maybe an important index in guiding clinical treatment.Combining the expression of VEGF with molecular subtype of breast cancer can contribute to judge the malignant degree and prognosis of tumor,which maybe another important index in guiding molecular subtype.