Abstract: Objective: To investigate the effects of prospective nursing on the quality of life and negative emotions in patients with acute myocardial infarction,and provide the reference for clinical nursing.Methods: One hundred and twenty patients with acute myocardial infarction were randomly divided into the observation group and control group(60 cases each group).The control group and observation group were treated with conventional nursing and prospective nursing,respectively.The quality of life and improvement of negative emotion between two groups were compared.Results: The scores of SDS in observation group were lower than those in control group(P<0.01).The scores of physical function,psychological function and social function in observation group were higher than those in control group(P<0.05).Conclusions: Prospective nursing can reduce the anxiety and depression of patients,and improve their quality of life,which is worthy of clinical application.