Abstract: Objective: To investigate the efficacy and safety of transurethral resection for benign prostatic hyperplasia (BPH) and bladder neoplasm in one-stage.Methods: The clinical date of 50 cases of bladder neoplasm with BPH were retrospectively analysed.Results: All operations were successful and no case was conversed to open surgery.No one received blood transfusion and no severe complication was observed.The average operation time,hospitalization time and total operative blood loss were (78±23) min, (6.4±2.0) days and (90±39) ml,respectively.The follow-up period ranged from 5 to 30 months.Recurrence rate at average follow-up period of 15 month was 12% (6/50).There was no implantation of urethral and bladder orificium fistulae.There were significant differences in IPSS,residual urine and maximum flow rate (P<0.01).Conclusions: Transurethral resection is a safe surgery therapy which can be recommended as an effective treatment for BPH with bladder neoplasm in one-stage.