Abstract: Objective: To explore the application value of the fast tracksurgery(FTS) concept in the anesthesia of esophageal cancer operation.Methods: Sixty esophageal cancer patients scheduled by operation were randomly divided into the fast tracksurgery treatment group(observation group,30 cases),who were treated with combined general-epidural anesthesia surgery,the restrictive transfusion management,warming blanket insulation in operation and epidural analgesia pump after operation,and regular operation group(control group,30 cases),who were treated with the general anesthesia surgery and conventional intravenous analgesia pump after operation.The serum cortisol and blood glucose levels between two groups were detected and compared before anesthesia,and at the time of cutting the skin,taking out the specimen and the end of surgery.The extubation time,anal exhaust time,hospitalization time and incidence of postoperative complications in two groups were observed.Results: The blood glucose and serum cortisol levels in control group at the time of cutting the skin,taking out the specimen and the end of surgery were significantly higher than those of before anesthesia(P<0.01),and each time-point of the observation group(P<0.01).Compared with these of before anesthesia in observation group,the changes of the blood glucose levels at the time of cutting the skin,taking out the specimen and the end of surgery were no obvious(P>0.05),and the serum cortisol levels significantly increased(P<0.01).The postoperative extubation time,anal exhaust time and hospitalization time in observation group were less than those in control group(P<0.05 to P<0.01),the difference of the incidence of complication between two groups was not statistically significant(P>0.05).Conclusions: The application of the fast tracksurgery concept in the anesthesia of esophageal cancer operation can promote the recovery of patients.