HA与CAG方案治疗老年人急性非淋巴细胞白血病疗效比较

Clinical efficacy of HA and CAG regimen on elderly patients with acute non-lymphocytic leukemia

摘要: 目的:观察三尖杉酯碱+阿糖胞苷(HA)与阿克拉霉素+阿糖胞苷+重组人粒细胞集落刺激因子(CAG)方案治疗老年人急性非淋巴细胞白血病(acute non-lymphocytic leukemia,ANLL)的疗效。方法:将32例老年人ANLL患者随机均分为HA与CAG方案组,比较两组患者的疗效。结果:CAG方案组患者的完全缓解率为56.3%,HA方案组为43.8%,两组总有效率分别为68.8%和62.5%,差异无统计学意义(P>0.05)。结论:CAG化疗方案比HA方案更适于老年ANLL患者,值得临床推广使用。

Abstract: Objective:To compare the clinical effects of harringtonine+arabinosylcytosin (HA) and aclarubicin+arabinosylcytosin+recombinant human granulocyte-colony stimulating factor (CAG) regimen in treatment of acute non-lymphocytic leukemia (ANLL) in the elderly.Methods:Thirty-two elderly patients with ANLL were randomly divided into HA group and CAG group,and the clinical efficacy was compared between the two groups.Results:The complete remission rate was 56.3% in the CAG group and 43.8% in the HA group.The total efficacy rates were 68.8% and 62.5%,respectively.The difference was not significant (P>0.05).Conclusions:CAG regimen is more suitable than HA regimen in treatment of ANLL in the elderly.It is worth popularizing.