丙种球蛋白治疗婴幼儿重症肺炎的疗效观察
Effect of intravenous gamma globulin on infants with severe pneumonia
-
摘要: 目的: 探讨婴幼儿重症肺炎的临床特点及大剂量丙种球蛋白(IVIG)的治疗效果。方法: 回顾分析54例婴幼儿重症肺炎的临床特点并将其随机分成两组:对照组28例给予抗生素等对症支持治疗,治疗组26例在对照组治疗的基础上应用IVIG1g.kg-1.d-1,连用2天,记录两组治疗前后临床症状、体征、胸片、并发症恢复情况的改变。结果: 婴幼儿重症肺炎病情重,病情变化快,多以呼吸困难为首发表现,肺外并发症以心力衰竭多见,辅助应用IVIG,每天1次静脉滴注,连用2天,临床症状改善或体征消失、好转快,明显优于对照组(P<0.001)。结论: 婴幼儿重症肺炎须及时救治,早期运用IVIG有助于缓解症状,提高治愈率。Abstract: Objective: To study the efficiency of intravenous immunoglobulin (IVIG) on infants with severe pneumonia. Methods: Fifty-four children with severe pneumonia were administered different therapies. Twenty-six children received large dose of IVIG (1 g·kg-1·d-1) daily in addition to routine treatment for 2 days, while other 28 children in the control group received only routine treatment. Results: Dyspnea was the most common symptom in infants with severe pneumonia. The symptom in the therapy group improved more rapidly than that in the control group. The difference was significant (P<0.001). Conclusions: IVIG can decrease the symptom and increase the cure rate in infants with severe pneumonia.
下载: