Abstract: Objective: To observe the effect of atorvastatin on cardiac function,C-reaction protein (CRP) and serum level of brain natriuretic peptide (BNP) in patients of heart failure (HF) with dilated cardiomyopathy (DCM). Methods: Forty patients with DCM and HF were randomly divided into treatment group and control group. The control group was given conventional drug therapy. The treatment group was given atorvastatin (40 mg/d,12 weeks) in addition to routine treatment. The left ventricular ejection fraction (LVEF),CRP and BNP were measured before and after treatment. Results: After 12 weeks,the LVEF was dramatically higher in all patients (P<0.01),and the LVEF in treatment group was significantly higher than that in the conventional therapy group (P<0.01). The serum level of CRP and BNP was dramatically lower in all patients (P<0.01). Also,the serum level of CRP and BNP was significantly lower in the treatment group when compared with that of control group (P<0.01). Conclusions: Short-term use of atorvastatin can decrease serum levels of CRP and BNP in Patients of HF with DCM,and improve cardiac function. The mechanism of action may be related to anti-inflammatory effect. It may be useful to short-term use of statin therapy.