Objective To study the effect of Helicobacter pylori (HP) infection on the clinical symptoms and serum inflammatory factors in patients with Parkinson's disease (PD).

Methods Hospitalized PD patients were selected as the research subjects. All enrolled patients were evaluated by clinical scale, and the infection of HP was detected by 13C-UBT method. The levels of serum inflammatory factors IL-1 β and IL-6 in PD patients were detected by enzyme-linked immunosorbent assay (ELISA). The clinical symptoms and serum levels of inflammatory factors IL-1 β and IL-6 in HP positive group, HP negative group and healthy people (control group) were compared; the relationship between the levels of serum inflammatory factors IL-1 β, IL-6 and clinical symptoms was analyzed.

Results Among 106 PD patients, 52 were HP positive; The serum levels of IL-1 β and IL-6 in HP positive group were significantly higher than those in HP negative group and control group (P ＜ 0.05); The levels of serum inflammatory factors IL-1 β and IL-6 in PD patients were positively correlated with the scores of UPDRS, SDS, SAS, PSQI scale and the onset time of drugs (P ＜ 0.01), and negatively correlated with the MOCA and "on" time (P ＜ 0.05). There were statistically significant differences in SAS, drug onset time and "on" time between HP positive group and HP negative group (P ＜ 0.05 to P ＜ 0.01).

Conclusion The HP infection rate of PD patients is high, the serum inflammatory factor level of PD patients increases, and HP infection aggravates the inflammatory reaction of PD patients, prolongs the onset time of anti PD drugs, and shortens the "on" period. The level of serum inflammatory factors has a certain correlation with the clinical symptoms of PD patients. Inflammatory response may be involved in the pathophysiological mechanism of the occurrence and development of PD.