Abstract: Objective: To discuss the value of liver blood pool SPECT in diagnosis of hepatic hemangioma.Methods: Twenty-two patients with clinically suspected hepatic hemangioma 1.5-9.1 cm in diameter were examined by hepatic conventional and blood pool SPECT and the results were compared with the histology and radiolgy outcome.Results: Of the 22 cases clinically suspected hepatic hemangioma,18 were diagnosed as hepatic hemangioma by SPECT,which were verified by pathological test (n=12),and clinical,radiological and serum tumor makers follow-up lasting for 2-3 years(n=6).In the other 4 cases,3 were proved hepatogenic cancers and 1 liver cyst by pathology.Conclusions: The liver blood pool SPECT is sensitive and specific in diagnosis of hepatic hemangiomas,and can be used to differentiate benign lesion from malignant lesion.