Abstract: Objective: To observe the postoperative palinesthesia and analgesia effect of flurbiprofen axetil on patients with general anesthesia.Methods: One hundred and twenty patients(ASAⅠ-Ⅱ) receiving general anesthesia were randomly divided into flurbiprof axetil group(group F),morphine group(group M),control group(group C).Before the abdominal membrane was closed up,group F were given intravenous injection of flurbiprofen axetil 50 mg,group M intravenous injection of morphine 4 mg and group C not any drugs.The time of palinesthesia,time of extubation,detention time in recovery room,postoperative palinesthesia,incidence rate of complication in eight hours,postoperative analgesia degree score and the number of patients needing to take pain-killing drugs because of pain in 2,4,6 and 8 h after operation were observed.Results: The time of palinesthesia,time of extubation and detention time in recovery room in group F were shorter than that in group M(P<0.01);there was no significant difference between group F and group C in the time of palinesthesia(P>0.05),but the defference was significant in time of extubation and detention time in recovery room(P<0.01);the incidence of complication was lowered in the time of palinesthesia;VAS score had no statistical difference at 2 h after operation among the 3 groups(P>0.05).The pain degree in group F and group M was signifantly lowered compared with that of group C(P<0.01),but the difference was not significant between group F and group M at 4 h,6 h and 8 h after operation(P>0.05).The number of patients needing to take pain-killing drugs in the three groups had no statistical difference at 2 h,4 h,6 h and 8 h after operation.Conclusions: Administration of flurbiprofen axetil before the end of operation has analgesia effect on patients receiving general anesthesia,and may decrease the incidence of complication at the time of palinesthesia without affecting the course of palinesthesia.