血清维生素D水平在外周T细胞淋巴瘤患者预后中的意义

董毅; 朱太岗; 李月红; 张飞虎; 夏瑞祥

doi:10.13898/j.cnki.issn.1000-2200.2017.02.009

血清维生素D水平在外周T细胞淋巴瘤患者预后中的意义

Significance of the serum vitamin D level in evaluating the prognosis of patients with peripheral T-cell lymphoma

摘要

摘要: 目的：探讨血清维生素D在外周T细胞淋巴瘤（peripheral T-cell lymphoma，PTCL）中的表达水平及临床意义。方法：选取51例初诊PTCL患者（初治组）及正常健康人（对照组）20名，采用化学发光法测定血清25-羟基维生素D25（OH）D的表达水平。结果：PTCL患者血清25（OH）D的表达在初治组为20.110 ng/mL，低于对照组的48.812 ng/mL（P<0.01）。初治PTCL患者血清25（OH）D的表达水平与疗效呈正相关关系（P<0.05），与分期、国际预后指数评分呈负相关关系（P<0.01）。结论：监测血清25（OH）D的表达水平有助于非霍奇金淋巴瘤的疗效及预后评定。

Abstract: Objective:To detect the serum vitamin D level in patients with peripheral T-cell lymphoma(PTCL),and its clinical significance.Methods:Fifty-one newly diagnosed PTCL patients and 20 healthy people were divided into the newly diagnosed group and control group,respectively.The serum expression levels of 25-hydroxy vitamin D25(OH)D in two groups was determined by chemiluminescence method.Results:The level of 25(OH)D in newly diagnosed group(20.110 ng/mL) was lower than that in control group(48.812)ng/mL(P<0.01).The serum level of 25(OH)D in newly diagnosed group was positive correlation with the therapeutic efficacy(P<0.05),and negative correlation with the clinical stage and IPI score(P<0.01).Conclusions:The level of 25(OH)D is useful in estimating the therapeutic efficacy and prognosis in patient with PTCL.

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