Abstract: Objective: To evaluate the value of magnifying endoscopy combined with Fuji intelligent chromoendoscopy(FICE) in the diagnosis of gastric cancer and precancerous lesions.Methods: The gastric mucosa gland openings and microvascular morphology in 109 patients(116 lesions) were detected by magnifying endoscopy combined with FICE,all cases were divided into six types according to the examination result.The clear gastric mucosa gland,clear and regular or irregular and unclear microvascular pattern were the main manifestations of types Ⅰ,Ⅱ and Ⅲ,the unclear and irregular gastric mucosa gland,clear and regular or irregular and unclear microvascular pattern were the main manifestations of types Ⅳ,Ⅴ and Ⅵ.The pathological results of different types were analyzed.Results: The type diagnosis of gastric mucosa gland using magnifying FICE was better than that using normal endoscope(P< 0.01).Compared with the magnifying chromoendoscopy,the magnifying FICE could clearly show the microvascular pattern(P< 0.01),the difference of the identifying the gastric mucosa gland opening between two methods was not statistically significant(P >0.05).Except for 1 HGD case,the canceration in case with clear and regular gastric mucosa gland opening(typeⅠto Ⅲ) was not found.The HGD and canceration located mainly in cases with unclear and irregular gastric mucosa gland opening(type Ⅳ to Ⅵ).Conclusions: Observing the microstructure of gastric lesions using magnifying FICE can guide the accurate biopsy,and improve the accuracy of diagnosing in gastric cancer.