大豆异黄酮对大鼠血脂和抗脂质过氧化作用的探讨

庄颖; 赵红; 张玉媛; 马孺林; 韩慧

大豆异黄酮对大鼠血脂和抗脂质过氧化作用的探讨

Influence of soybean isoflavone on the fat level and anti-lipid peroxides in rats

摘要

摘要: 目的: 以喂养高胆固醇饲料造成高脂血症(HC)的大鼠为研究对象,观察大豆异黄酮(SI)对大鼠血脂水平及体内过氧化状态的影响。方法: 50只Wistar大鼠随机分为5组,分别接受基础饲料、高脂饲料及高脂饲料分别添加大豆异黄酮30 mg/kg、90 mg/kg和270 mg/kg处理。实验6周。结果: 高剂量SI显著抑制高脂饲料所致的血浆低密度脂蛋白升高(P<0.01)。SI对进食高脂饲料引起的体内脂质过氧化物升高具有拮抗作用,并可提高谷胱甘肽过氧化物酶、超氧化物歧化酶和过氧化氢酶的抗氧化活性(P<0.05~P<0.01)。结论: SI对高甘油三酯有降低作用,并能改善高脂所致体内异常的过氧化状态,减轻对机体的过氧化损伤。

Abstract: Objective: To observe the influence of soybean isoflavone(SI) on the fat level and lipid peroxides in rats.Methods: Fifty wistar rats were randomly divided into five groups and fed on foundation feed high fat feed,and high fat feed mixed with 30 mg/kg,90 mg/kg and 270 mg/kg soybean isoflavone respectively.The experiment lasted for 6 weeks.Results: SI could obviously inhibit the rise of low density lipoprotein(LDL) induced by high fat feed in the plasma(P<0.01).SI had preventive effect on the rise of lipid peroxide induced by feed and it improved the activity of GSH px,SOD and CAT(P<0.05 to P<0.01).Conclusions: SI can decrease the hypertriglyceride,improve the abnormal oxidization caused by high fat feed,and alleviate the lesion due to peroxidation.

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