Abstract: Objective: To observe the cardiovascular response during extubation in patients who have received general anesthesia by vein injection of tramadol.Methods: Forty patients were randomly divided into observation group and control group,with 20 patients in each.Use of anesthesia was halted half hour before the completion of operation,then tramadol 1.5 mg/kg was administered intravenously to the patients in the observation group,but no medicine was given to the control group.The SBP,DBP,HR at the moment of injection,the time of phlegm sucking,the moment of extubation and 1 minute and 5 minutes after extubation were observed.Results: The SBP,DBP and HR increased significantly at the moment of phlegm sucking,extubation,and 1 minute after extubation in the control group,compared with those at the moment of injection(P<0.01).And The SBP,DBP and HR decreased slightly at 5 minutes after extubation;however the SBP was still higher than that at the moment of injection(P<0.05).In the observation group,the SBP,DBP,HR were stable and increased slightly during the above mentioned moments,and their difference with the moment of injection was not significant(P>0.05).The patients come back stably,with no mania or pain on the wound.Conclusions: Tramadol can effectively relieve the cardiovascular response at extubation for patients receiving general anesthesia.