Abstract: Objective: To investigate the effects of daily wake-up strategy on multiple trauma patients receiving postoperative sedation and analgesia.Methods: Thirty-six patients with multiple traumas were analyzed retrospectively.All the cases who were transferred to ICU after operation and received mechanical ventilation and sustained implementation of fentanyl and midazolam were divided into wake-up group(n=18) and control group(n=18).The patients in the wake-up group were applied daily wake-up strategy and special care interventions,while the control group received only the routine treatment and care.The dosage of sedative and analgesic drugs,the duration of mechanical ventilation,the length of ICU stay and the hospital cost were compared between the two groups.Results: The differences were statistically significant(P<0.05 to P<0.01) in the wake-up group and the control group in the dosage of sedative and analgesic drugs,duration of mechanical ventilation,length of ICU stay and hospital costs.Conclusions: The daily wake-up strategy combined with proper nursing care may not only reduce the dosage of sedative and analgesic drugs,shorten the length of mechanical ventilation and ICU stay but decrease the hospital cost for the multiple trauma patients receiving postoperative sedation and analgesia.