小牛血去蛋白提取物注射液治疗Alzheimer病临床研究

Deproteinized hemoderivative of calf blood injection for the treatment of Alzheimer disease

摘要: 目的:观察小牛血去蛋白提取物注射液(deproteinized hemoderivative of calf blood injection,DHCBI)对阿尔茨海默病(Alzheimer disease,AD)的临床疗效。方法:将66例随机分为两组,对照组静脉用吡拉西坦注射液,治疗组静脉用DHCBI,2周为1疗程,观察两组的治疗效果。结果:两组的临床症状有所改善,两组的血浆高敏C反应蛋白(hsCRP)和血脂各指标均有改善(P<0.01),但以治疗组为优(P<0.05~P<0.01)。结论:DHCBI可以改善老年AD患者血浆炎症和血脂水平。

Abstract: Objective: To observe the effects of deproteinized hemoderivative of calf blood injection(DHCBI) on Alzheimer disease.Methods: Sixty-six patients were randomly divided into control group and treatment group.The control group received the therapy of piracetam intravenous injection,and the treatment group received intravenous DHCBI.One course lasted fo two weeks,and then the therapeutic effects were observed.Results: The clinical symptoms and the plasma high-sensitivity C-reactive protein and various lipid indicators of the two groups improved(P<0.01),and there were more obvious effects in the treatment group(P<0.05-P<0.01).Conclusions: DHCBI can improve the plasma lipid and the inflammation levels of the elderly with Alzheimer disease.