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    Box-Behken响应面法结合多指标综合评分法优化解郁清心颗粒的提取工艺

    The extraction process of Jieyu Qingxin granuLes was optimized by Box-Behken response surface method with multi-index comprehensive scoring method combined

      摘要
    • 摘要:
      目的： 优选解郁清心颗粒的最佳水提工艺。
      方法： 以浸泡时间、加水量、煎煮时间为考察因素，以出膏率及干膏中芍药苷、芍药内酯苷、甘草苷、甘草酸的含量为考察指标，采用Box-Behken响应面法优化解郁清心颗粒的煎煮工艺。
      结果： 优选出解郁清心颗粒的最佳水提工艺为煎煮2次，浸泡时间90 min，加水量10倍，煎煮时间120 min。经3次试验验证，所得平均综合得分为7.802。
      结论： Box-Behken响应面法结合多指标综合评分法优化得到的解郁清心颗粒的最佳煎煮工艺稳定可行。

       

      Abstract:
      Objective To optimize the water extraction process of Jieyu Qingxin granules.
      Methods Extraction time, amount of water added and soaking time were considered as factors, the extraction process of Jieyu Qingxin granuLes was optimized by Box-Behken response surface method, with the paste yield and the contents of paeoniflorin, aLbiflorin, liquiritin and glycyrrhizic acid.
      Results The optimaL water extraction process of Jieyu Qingxin granuLes was determined to be two extractions, each lasting 120 minutes, with 10 volumes of water added and a soaking time of 90 minutes. After three experiments, the average composite score was 7.802.
      Conclusions The optimal extraction process of Jieyu Qingxin granules obtained by Box-Behken response surface method with multi-index comprehensive scoring method combined which is stable and feasible.

       

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