Abstract: Objective:To explore the effect of immunoglobulin(IG) on patients with end stage liver diseases combined with infection. Methods:One hundred and five patients with end stage liver diseases combined with infection were randomized into treatment group (53 cases) and control group (52 cases). The control group received the routine therapy of antibiotics and the treatment group were administered IG in addition to the antibiotics. The clinical effect was evaluated according to the Child-Pugh score. Results:The patients with the score of Child-Pugh < 10 in the two groups presented increased total bilirubin,decreased cholesterol and prolonged prothrombin time after one week's therapy, and there were no significant differences between the two groups. In patients with the score of ChildPugh 10-15, the percentage of efficiency was 80.00% and 46.15% (P<0.05) in the study group and the control group respectively,and the percentage of inefficiency was 20.00% and 53.85% (P<0.05). Conclusions:Early therapy of IG can effectively increase the anti-infection ability of patients with end stage liver diseases combined with infection whose score of Child-Pugh is 10-15, and may help to reduce the mycotic double infection.