Abstract: Objective: To observe the effect and side effect of docetaxel combined with oxaliplatin in the treatment of non-small cell lung cancer(NSCLC).Methods: Thirty-four patients with advanced NSCLC(Karnofsky score ≥ 60,expectancy life span ≥ 3 months) were included in the sstudy.Docetaxel 75 mg/m² was administrated in intravenous infusion at day 1 and oxaliplatin 130 mg/m² was administrated at day 2.One cycle consisted of 21 days and the clinical response was assessed after two cycles.Results: Of the 34 patients,CR was achieved in 0,PR in 8,SD in 19 and PD in 7.The response rate was 23.5%.The main side effects were peripheral neuritis and inhibition of bone marrow.Conclusions: Combination therapy of docetaxel and oxaliplatin is effective on advanced NSCLC with acceptable toxicity and especially suitable for elderly and drug resistant patients.