Abstract: Objective:To comprehend the infect condition of human papilloma virus(HPV) in patients with condyloma acuminatum(CA).Methods:The real-time FQ-PCR method was established to detect HPV type 6,11,16 and 18 in 68 samples from patients with condyloma acuminatum and 160 samples from subclinical patients.Results:The positive rates of male and female were 78.99%and 77.78%,respectively,there was no stastical significance(P>0.05).Detection rates of CA tissues and subclinical tissues were 95.59% and 71.25%,respectively,with the stastical significance(P<0.01).Among the 179 HPV positive patients,76.54% were infected with HPV type 6 and type 11, 8.94% were infected with HPV type 16 and type 18, 14.52%were mixed infection with HPV type 6,11,16 and 18.Conclusions:The HPV infective rate in male is as same as in female; and the detection rate of CA is higher than in other samples; HPV type 6 and type 11 infection are the main reasons in our region.