原发性卵巢甲状腺肿类癌4例临床病理分析

    The clinical pathology analysis of primary ovarian strumal carcinoid in 4 cases

    • 摘要: 目的:探讨原发性卵巢甲状腺肿类癌(POSC)的临床病理特征。方法:应用光镜、免疫组织化学、特殊染色技术对4例POSC进行临床病理分析。结果:患者临床表现为腹痛及盆腔肿块,无便秘、类癌综合征表现,其中2例以卵巢囊状肿块蒂扭转为首发症状。组织学上甲状腺肿与类癌相移行,部分类癌细胞排列成岛状或梁状,1例伴有交界性黏液性囊腺瘤成分,3例伴有成熟性畸胎瘤。免疫表型:类癌细胞神经细胞黏附分子、突触素、嗜铬素、神经元特异性烯醇化酶均阳性。结论:POSC是一种罕见的生殖细胞肿瘤,形态学上需要与卵巢粒层细胞瘤、Sertoli-Leydig细胞瘤等相鉴别,HE切片及免疫组织化学标记可以有效地帮助诊断。

       

      Abstract: Objective: To investigate the clinicopathological characteristics of primary ovarian strumal carcinoid(POSC).Methods: The clinicopathological characteristics of POSC in 4 cases were analyzed by light microscopy,immunohistochemistry and special stains.Results: The patients' clinical manifestations were lower abdominal pain,and no constipation and carcinoid syndrome.Ovarian cystic masses torsion was the initia symptom in 2 cases.The goiter and carcinoid tissue were transition,part cancer cells arranged in island or beam.The borderline mucinous cystadenoma in 1 case and mature teraloma in 3 cases were found.The neural cell adhesion molecule of immune phenotype cancer cells,synaptophysin,chromogranin and neuron specific enolase were positive.Conclusions: POSC is a rare germ cell tumor,which should be differentiated from granulosa cell tumor and Sertoli-Leydig cell tumor.HE and immunohistochemical stain will contribute to the diagnosis.

       

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