纳洛酮治疗新生儿缺氧缺血性脑病的临床观察

Treatment of neonatal hypoxic ischemic encephalopathy with naloxone

摘要: 目的: 观察纳洛酮治疗中、重度新生儿缺氧缺血性脑病(HIE)的疗效。方法: 在常规治疗的基础上,对32例加用纳洛酮,并与对照组20例比较。结果: 两组临床症状和体征恢复时间差异均有显著性(P<0。05~P<0。01)。结论: 纳洛酮治疗中、重度新生儿缺氧缺血性脑病的疗效高于一般常规治疗。

Abstract: Objective: To observe the clinical effect of naloxone in the treatments of neonatal hypoxic ischemic encephalopathy(HIE).Methods: Combination therapy of naloxone and routine treatment was applied to 32 newborn with HIE and 20 other newborn with HIE receiving only routine treatment as control.Results: The time for disappearance of clinical symptoms and recovery was shorter in the treatment group than in the control group(P<0.05 to P<0.01).Conclusions: The therapeutic effect of naloxone in the treatment of HIE is apparently better than that of routine therapy.