原发性干燥综合征62例血清学特点分析

    Serological analysis of 62 cases of primary Sjogren's syndrome

    • 摘要: 目的:探讨原发性干燥综合征(primary Sjogren's syndrome,pSS)患者的血清学特点,提高对该病的认识。方法:对符合2002年修订的国际分类(诊断)标准的62例pSS患者的临床资料、血清学和免疫学进行分析。结果:早期表现不典型,首发症状以口眼干燥、低钾血症和关节痛表现多见,而雷诺现象者少见。实验室检查ANA(+)、SSA-52KD(+)者多见,分别为83.9%和85.5%,RF滴度、IgG增高分别为72.6%、79.0%。pSS患者CD4+T细胞表达水平(32.0±8.4)%低于参考值(47.2±5.8)%,CD4+/CD8+比值降低。NK细胞CD16+56+表达为(5.8±2.6)%,低于正常参考值(10.0±3.8)%。结论:pSS患者血清中SSA-52KD阳性率较高,T细胞亚群中CD4+表达低于正常,CD4+/CD8+比值降低,CD16+56+表达水平降低,提示存在免疫功能紊乱及免疫功能低下,预示可能会发生淋巴瘤。

       

      Abstract: Objective:To investigate the serological characteristics and immunological features of primary Sjogren's syndrome (pSS).Methods:A total of 62 patients with pSS were studied.All the cases was were diagnosed according to the American European consensus criteria (AECC) of 2002.The main clinical and immunological features were analyzed.Results:The common initial clinical symptoms included xerostomia,xerophthalmia,hypokalemia and arthralgia.Reynaud phenomenon was rarely seen.Positive ANA and anti-SSA52 (+) antibodies were frequently detected (83.9% and 85.5%).The rates of RF titer and IgG levels were 72.6% and 79.0% respectively.The percentage of CD4+ T cells and the ration of CD4+/CD8+ T cells in peripheral blood of pSS patients were lower than that of healthy controls.The expression rate of CD16+56+ in peripheral bloods of pSS patients (5.8±2.6)%were lower than that of reference value (10.0±3.8)%.Conclusions:Anti-SSA-52 (+) antibody is a frequent immunological marker among pSS patients.Low CD4+/CD8+ T-lymphocyte ratio may be a significant risk factor for the development of lymphoma in pSS.Lower expression of CD16+56+ determines the extent to which the NK cells lose the immune supervision,which may increase the incidence of lymphoma in pSS patients.

       

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