Abstract: Objective: To observe the clinical effects and safety of ozagrel in treatment of acute ischemic stroke. Methods: One hundred and sixty-two patients with acute ischemic stroke were randomly divided into control group and treatment group, each 81 patients. The patients in control group were treated with common western medicine,while in treatment group was given ozagrel except the common western medicine. Before and after 14 days' treatment,the neurologic impairment and clinical curative effect in the two groups were evaluated. Results: The therapeutic effect rate in the treatment group was 88.89%,and that in control group was 76.54%, there was significantly statistical difference in the two groups(P < 0.01). Conclusions: Ozagrel is effective and safe in treatment of acute ischemic stroke and worthy of being widely used in clinic.