Abstract: Objective: To evaluate the therapeutic effects of different methods on hepatolithiasis.Methods: The clinical data of 125 patients with hepatolithiasis were reviewed and analyzed retrospectively.Results: Two cases died at periopration(1.6%) and 6 cases had residual stones(4.8%).Seventy-three cases were followed up.Fourteen cases reoccurred,5 cases were treated by chloedochoscopy per subcutaneous blind loop,3 cases received reoperation and 4 cases anti-infection therapy.Conclusions: It is essential to release obstruction and remove focus in the treatment of hepatolithiasis.The patterns of operation should be chosen according to different situation.