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    乙型肝炎患者血清乙型肝炎病毒-DNA与常用血清标志物的相关性分析

    Correlation between HBV-DNA and routine serum markers in patients with hepatitis B virus infection

      摘要
    • 摘要: 目的: 评估乙型肝炎(乙肝)患者血清乙肝病毒DNA(HBV-DNA)载量与血清免疫和生化标志物之间的关系。方法: 收集214例乙肝患者血清, 分别用荧光定量PCR法、化学发光法和速率法检测血清中的HBV-DNA、乙肝病毒表面抗原(HBsAg)、乙肝病毒e抗原(HBeAg)和丙氨酸氨基转移酶(ALT), 分析各标志物之间的关系。结果: 214例中, HBV-DNA阳性率为57.48%;HBeAg阳性率为28.04%。HBV-DNA载量与HBsAg和ALT水平均无相关关系(P>0.05), 但与HBeAg水平密切相关(P<0.01), HBV-DNA阳性组的HBeAg和ALT水平均明显高于HBV-DNA阴性组(P<0.01)。结论: HBV-DNA载量与HBeAg水平呈正相关关系, 与HBsAg和ALT水平无相关性, HBsAg水平作为HBV-DNA的替代方法仍需进一步验证。

       

      Abstract: Objective: To explore the correlation between hepatitis B virus(HBV)-DNA load and routine serum markers in patients with HBV infection.Methods: The serum HBV-DNA,hepatitis B virus surface antigen(HBsAg),hepatitis B virus e antigen(HBeAg) and alanine aminotransferase(ALT) in 214 patients with HBV infection were detected using TaqMan real time polymerase chain reaction,chemiluminescence and rate assay.The relationship between the markers were analyzed.Results: Among the 214 patients,the positive rates of HBV-DNA and HBeAg were 57.48% and 28.04%,respectively.The HBV-DNA load was not related to HBsAg and ALT(P>0.05),and was closely related to the HBeAg level(P<0.01).The levels of HBeAg and ALT in positive HBV-DNA group were significantly higher than those in negative HBV-DNA group(P<0.01).Conclusions: The HBV-DNA load is positive correlation with the HBeAg level,and is not correlation with HBsAg and ALT.The HBsAg level standing for HBsAg still nends be further validated

       

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