刘扬, 孙中武. 血清β-淀粉样蛋白与tau蛋白在皮质下缺血性血管性痴呆早期诊断的应用价值[J]. 蚌埠医学院学报, 2011, 36(3): 227-230.
    引用本文: 刘扬, 孙中武. 血清β-淀粉样蛋白与tau蛋白在皮质下缺血性血管性痴呆早期诊断的应用价值[J]. 蚌埠医学院学报, 2011, 36(3): 227-230.
    LIU Yang, SUN Zhong-wu. Value of serum β amyloid protein and tau protein in early diagnosis of subcortical ischemic vascular dementia[J]. Journal of Bengbu Medical College, 2011, 36(3): 227-230.
    Citation: LIU Yang, SUN Zhong-wu. Value of serum β amyloid protein and tau protein in early diagnosis of subcortical ischemic vascular dementia[J]. Journal of Bengbu Medical College, 2011, 36(3): 227-230.

    血清β-淀粉样蛋白与tau蛋白在皮质下缺血性血管性痴呆早期诊断的应用价值

    Value of serum β amyloid protein and tau protein in early diagnosis of subcortical ischemic vascular dementia

    • 摘要: 目的: 探讨血清β-淀粉样蛋白(Aβ)与tau蛋白在皮质下缺血性血管性痴呆(SIVD)早期诊断中的应用价值。方法: 采用ELISA法分别检测38例SIVD患者、42例伴皮层下血管性特征的轻度认知功能损害(MCI-V)患者以及36名正常对照者的血清Aβ38、Aβ40、Aβ42、总tau(tau)蛋白和磷酸化tau(p-tau)蛋白的水平。结果: SIVD组的Aβ40水平均显著高于MCI-V组和对照组(P<0.01),MCI-V组高于对照组(P<0.05);3组Aβ38和Aβ42水平差异均无统计学意义(P>0.05)。SIVD组的tau水平均显著高于MCI-V组和对照组(P<0.01),MCI-V组高于对照组(P<0.05);SIVD组p-tau水平均高于MCI-V组和对照组(P<0.05)。结论: 血清Aβ40和tau蛋白可以作为SIVD早期诊断的生物学指标。

       

      Abstract: Objective: To explore the value of serum β amyloid protein (Aβ) and tau (tau) protein in early diagnosis of subcortical ischemic vascular dementia (SIVD). Methods: ELISA method was used to detect the levels of serum Aβ38,Aβ40,Aβ42,tau protein and excessive phosphorylated tau protein (p-tau) in 38 patients with SIVD,42 patients with mild cognitive impairment accompanied by subcortical vascular features (MCI-V) and 36 controls. Results: The Aβ40 level of SIVD group was significantly higher than that of the other two groups (P<0.01),and the Aβ40 level of MCI-V group was higher than that of the controls (P<0.05); The levels of Aβ38 and Aβ42 did not differ among the three groups (P>0.05). The tau level of SIVD group was significantly higher than that of the other two groups (P<0.01),and the tau level of MCI-V group was higher than that of the controls (P<0.05). The p-tau level of SIVD group was significantly higher than that of the MCI-V group and the controls (P<0.05). Conclusions: The levels of the serum Aβ40 and tau protein may act as meaningful biomarkers in early diagnosis of SIVD.

       

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