张运彩, 赵锦, 李胜泽. 宫颈鳞癌中RECK与MMP-9的表达及意义[J]. 蚌埠医学院学报, 2016, 41(9): 1201-1204. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.026
    引用本文: 张运彩, 赵锦, 李胜泽. 宫颈鳞癌中RECK与MMP-9的表达及意义[J]. 蚌埠医学院学报, 2016, 41(9): 1201-1204. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.026
    ZHANG Yun-cai, ZHAO Jin, LI Sheng-ze. Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma[J]. Journal of Bengbu Medical College, 2016, 41(9): 1201-1204. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.026
    Citation: ZHANG Yun-cai, ZHAO Jin, LI Sheng-ze. Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma[J]. Journal of Bengbu Medical College, 2016, 41(9): 1201-1204. DOI: 10.13898/j.cnki.issn.1000-2200.2016.09.026

    宫颈鳞癌中RECK与MMP-9的表达及意义

    Expression and significance of RECK and MMP-9 in cervical squamous cell carcinoma

    • 摘要: 目的:探讨宫颈鳞癌中逆转录富含半胱氨酸蛋白(RECK)和基质金属蛋白酶(MMP)-9的表达及意义。方法:应用免疫组织化学法,检测20例正常子宫颈组织及70例子宫颈鳞状细胞癌中RECK和MMP-9的表达。结果:RECK蛋白在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为95.00%和31.43%,差异有统计学意义(P<0.01);有淋巴转移组的阳性率较无淋巴转移组明显降低(P<0.01)。MMP-9在正常宫颈组织、子宫颈鳞癌组织中表达的阳性率分别为25.00%和80.00%,差异亦有统计学意义(P<0.01);MMP-9表达在宫颈鳞癌有淋巴转移组的阳性率较无淋巴转移组明显升高(P<0.01)。RECK及MMP-9在宫颈鳞癌中的表达呈负相关关系(P<0.01)。结论:RECK在宫颈鳞癌中表达减少或缺失可能是通过上调MMP-9的表达从而促进宫颈鳞癌的侵袭与转移,RECK和MMP-9与宫颈鳞癌的浸润转移密切相关。

       

      Abstract: Objective: To investigate the expressions and significance of RECK and matrixmetalloproteinase-9(MMP-9) in the cervical squamous cell carcinoma.Methods: The expressions of RECK and MMP-9 in 20 cases of normal cervical tissue and 70 cases of cervical squamous cell carcinoma were detected using immune histochemical staining method.Results: The positive rates of RECK protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 95.00% and 31.43%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of RECK in patients with lymph node metastasis significantly decreased(P<0.01).The positive rates of MMP-9 protein expression in normal cervical tissue and cervical squamous cell carcinoma tissue were 25.00% and 80.00%,respectively,the difference of which was statistically significant(P<0.01).Compared with the cervical squamous cell carcinoma patients without lymph node metastasis,the positive rate of MMP-9 in patients with lymph node metastasis significantly increased(P<0.01).The expression of RECK in cervical squamous carcinoma was negative correlation with the expression of MMP-9(P<0.01).Conclusions: The decreasing or absent of the RECK expression in cervical squamous carcinoma maybe though upregulate the expression of MMP-9 to promote the infiltration and metastasis of cervical squamous carcinoma.The RECK and MMP-9 are closely related to the infiltration and metastasis.

       

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