张强, 禹莉. 昂丹司琼联合甲氧氯普胺、维生素B_6治疗急性白血病化疗后胃肠道反应[J]. 蚌埠医学院学报, 2010, 35(6): 589-590,592.
    引用本文: 张强, 禹莉. 昂丹司琼联合甲氧氯普胺、维生素B_6治疗急性白血病化疗后胃肠道反应[J]. 蚌埠医学院学报, 2010, 35(6): 589-590,592.
    ZHANG Qiang, YU Li. Ondansetron combined with metoclopramide and vitamin B6 for gastrointestinal reaction induced by chemotherapy of acute leukemia[J]. Journal of Bengbu Medical College, 2010, 35(6): 589-590,592.
    Citation: ZHANG Qiang, YU Li. Ondansetron combined with metoclopramide and vitamin B6 for gastrointestinal reaction induced by chemotherapy of acute leukemia[J]. Journal of Bengbu Medical College, 2010, 35(6): 589-590,592.

    昂丹司琼联合甲氧氯普胺、维生素B_6治疗急性白血病化疗后胃肠道反应

    Ondansetron combined with metoclopramide and vitamin B6 for gastrointestinal reaction induced by chemotherapy of acute leukemia

    • 摘要: 目的:观察昂丹司琼联合甲氧氯普胺、维生素B6治疗急性白血病化疗后所致胃肠道反应的效果。方法:急性髓细胞白血病患者化疗第1~5天,每天化疗前30 min应用昂丹司琼8 mg加5% GS 100 ml静脉滴注;甲氧氯普胺20~30 mg(根据年龄及体重不同)和维生素B6100~200 mg加5% GS 100 ml化疗后4 h静脉滴注,连用5天。急性淋巴细胞白血病患者第1、8、15及21天每次化疗前30 min应用昂丹司琼;化疗后应用甲氧氯普胺、维生素B6,剂量及用法同急性髓细胞白血病患者。对照组患者每天化疗前30 min和化疗后4 h各单用昂丹司琼8 mg加5% GS 100 ml静脉滴注。结果:两组用药后恶心程度及镇吐效果差异均无统计学意义(P>0.05)。结论:昂丹司琼与甲氧氯普胺、维生素B6联合应用防治急性白血病化疗后胃肠道反应,其效果与反复使用昂丹司琼基本相同。

       

      Abstract: Objective:To investigate the therapeutic efficacy of ondansetron combined with metoclopramide and vitamin B6 on gastrointestinal reaction induced by chemotherapy of acute leukaemia.Methods:The patients with acute myeloid leukemia were intravenously injected 8 mg ondansetron and 100 ml of 5% GS 30 min before chemotherapy,and 20-30 mg metoclopramide,100-200 mg vitamin B6 and 100 ml of 5% GS 4 hours after chemotherapy for 5 days.The patients with acute lymphoid leukemia were given ondansetron 30 min before chemotherapy at the same dosage as the patients with acute myeloid leukemia.The patients in control group were given 8 mg ondansetron and 100 ml of 5% GS 30 min before chemotherapy and 4 hours after chemotherapy.Results:The degree of nausea and antiemetic effect had no statistical difference between the two groups (P>0.05).Conclusions:The combined therapy of ondansetron,metoclopramide and vitamin B6 has similar effect to repeated use of ondansetron on gastrointestinal reaction induced by chemotherapy of acute leukaemia.

       

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