Abstract: Objective: To study the pathogenesis of thrombocytopenia and its optimal treatment in perinatal period. Methods: Based on the treatment of primary disease, platelet counts > 50×10⁹/L and asymptomatic patients were given oral iron-supplementary, creatinine,folic acid and vitamins routinely. As for patients with platelet counts < 50×10⁹/L,they were treated with glucocorticoid, platelet and immunoglobulin in perinatal period, and the caesarean section was considered. Results: The main causes of thrombocytopenia included pregnancy itself in 24 cases,preeclampsia in 11 cases,idiopathic thrombocytopenic purpura in 4 cases,liver diseases in 2 cases,and aplastic anemia in 1 case of all cases. For all cases,vaginal delivery and cesarean section were 23 and 19 cases,respectively. Postpartum hemorrhage happened in 3 cases,and eonatal thrombocytopenia happened in 1 case. Conclusions: Many reasons may cause thrombocytopenia during pregnancy. Based on treatments for the cause,Application of platelet agent,corticosteroid and immune globulin is effective treatment for severe thrombocytopenia during pregnancy.