张丽娜, 屈洪党, 陈育华, 殷亮, 李倩倩. 血清尿酸水平与帕金森病不同运动亚型之间的关系[J]. 蚌埠医学院学报, 2017, 42(7): 852-853,857. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.004
    引用本文: 张丽娜, 屈洪党, 陈育华, 殷亮, 李倩倩. 血清尿酸水平与帕金森病不同运动亚型之间的关系[J]. 蚌埠医学院学报, 2017, 42(7): 852-853,857. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.004
    ZHANG Li-na, QU Hong-dang, CHEN Yu-hua, YIN Liang, LI Qian-qian. Association between the serum uric acid level and motor subtype of Parkinson's disease[J]. Journal of Bengbu Medical College, 2017, 42(7): 852-853,857. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.004
    Citation: ZHANG Li-na, QU Hong-dang, CHEN Yu-hua, YIN Liang, LI Qian-qian. Association between the serum uric acid level and motor subtype of Parkinson's disease[J]. Journal of Bengbu Medical College, 2017, 42(7): 852-853,857. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.004

    血清尿酸水平与帕金森病不同运动亚型之间的关系

    Association between the serum uric acid level and motor subtype of Parkinson's disease

    • 摘要: 目的:探讨血清尿酸(UA)水平与帕金森病(PD)不同运动亚型及临床分期之间的关系。方法:入选PD病人(PD组)及年龄、性别相匹配的健康对照组(HC组)各50例,PD病人根据运动障碍症状分为震颤为主型(TD组)和姿势异常及步态障碍为主型(PIGD组);病情严重程度采用Hoehn-Yahr(H-Y)分级评定为早期(H-Y<3级)及中晚期(H-Y≥3级)。分别测定各组血清UA水平,同时检测血清肌酐(Cr)水平。结果:PD组血清UA水平低于HC组(P<0.01);PIGD组血清UA水平较TD组明显降低(P<0.05);中晚期PD病人血清UA水平低于早期(P<0.01)。各组血清Cr水平差异无统计学意义(P>0.05)。结论:UA水平的变化可能参与了PD不同运动亚型的发病机制,并可能成为预测PD发病风险、判断病情严重程度及运动分型的生物学标志物。

       

      Abstract: Objective:To investigate the relationships between serum uric acid(UA) level,and different motor subtypes and clinical stage of Parkinson's disease(PD).Methods:PD patients and age and sex-matched healthy people were divided into the PD group(n=50)and control group(HC group,n=50),respectively.The PD group were subdivided into TD group(tremor-dominant) and PIGD group(postural instability and gait difficulty-dominant) according to the dyskinesia symptom.The disease severity was evaluated by Hoehn-Yahr(H-Y) scale,which could evaluated for early-stage(H-Y<3) and advanced-stage(H-Y≥3).The serum levels of UA and creatinine(Cr) in all cases were measured.Results:The serum UA level in PD group was lower than that in HC group(P<0.01).Compared with the TD group,the serum level of UA in PIGD group was significantly decreased(P<0.05).The serum level of UA in middle and advanced PD patients was lower that in early patients(P<0.01).The difference of the serum level of Cr between all cases was not statistically significant(P>0.05).Conclusions:The UA change may be involved in the pathogenesis of different motor subtypes of PD,which may be a potential useful biomarker in predicting risk,and diagnosing the severity and motor subtype of PD.

       

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