更昔洛韦治疗先天性巨细胞病毒感染疗效观察

Effect of ganciclovir on neonatal congenital cytomegalovirus infection

摘要: 目的: 观察更昔洛韦治疗先天性巨细胞病毒感染的临床疗效。方法: 将先天性巨细胞病毒感染患儿随机分为病毒唑治疗组(26例)及更昔洛韦治疗组(27例),对两组患儿的临床表现及治疗效果进行观察。结果: 病毒唑治疗组和更昔洛韦治疗组疗程结束后,在临床表现、实验室检查及病毒学结果转归方面进行比较,差异均有显著性(P<0。05)。结论: 更昔洛韦对先天性巨细胞病毒感染有显著疗效,且副作用小,值得临床推广。

Abstract: Objective: To observe the clinical effects of ganciclovir on neonatal congenital cylomegalovirus(CMV) infection.Methods: Fifty-three patients with neonatal congenital CMV infection were randomly divided into the virazole group(26 cases) and the ganciclovir group(27 cases),and the clinical manifestations and therapeutic effects were compared.Results: There were significant differences in the clinical manifestation,laboratory examination and virology test result between the virazole group and the ganciclovir group after treatment(P<0.05).Conclusions: Ganciclovir has obvious effects on neonatal congenital CMV infection with littler side effect,so it is worth widespreading in clinical practice.