Abstract: Objective: To explore the effects of the combined disconnection operation on preventing upper gastrointestinal hemorrhage of patients with portal hypertension.Methods: The muscle layer and mucosa blood vessels of lower esophagus were cut off using tubular anastomat through abdomen in 5 cases after splenectomy and cutting off peripheral vascular of cardia,which could prevent the upper gastrointestinal hemorrhage of patients with portal hypertension.The operation preparation,operation time,operation means and complication treatment of joint cut-out operation were analyzed.Results: Cure in 50 cases,death in 1 case,anastomotic fistula in 1 case and anastomotic stenosis in 1 case were found.Different degree ascites in 23 cases and fever in 9 cases were found after operation.All cases were followed up for 7 years,no hemorrhage occurred.Conclusions: The combined disconnection operation is an effective method to treat the upper gastrointestinal hemorrhage of patients with portal hypertension